Description

Tretiva 20 slows down the proliferation of epithelial cells of the ducts of the sebaceous glands, the formation of detritus, facilitates the evacuation of detritus, normalizes the terminal differentiation of cells. Isotretinoin facilitates secretion and reduces sebum production. After ingestion, the absorption of a substance is variable, the bioavailability is variable and low. Taking Tretiva 20 with food increases bioavailability by 2 times. The maximum plasma concentration is reached within 2-4 hours.

Indications for use of Isotretinoin:

• For rectal use and ingestion: acne, which are not amenable to other types of treatment; severe forms of acne.
• For local use: seborrheic dermatitis, common acne, perioral dermatitis, rosacea.

The dosage regimen of Tretiva 20 is set individually, because the adverse reactions and therapeutic efficacy of Isotretinoin are dose dependent and vary among different patients. The drug is taken orally during meals, the initial dose is 0.4 – 0.5 mg (per 2 pounds of weight) per day, which is divided into two parts, applied for 16 – 24 weeks.

In case of an overdose of Tretiva 20, symptoms of hypervitaminosis A may develop. Necessary: ​​gastric lavage in the first few hours after the overdose.